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Panobinostat


CAS Number: 404950-80-7

Mol.Formula: C21H23N3O2 

Mol.Weight: 349.43

Chemical Name: (2E)-N-hydroxy-3-[4-({[2-(2-methyl-1H-indol-3-yl)ethyl]amino}methyl)phenyl]acrylamide

Synonyms: Faridak; LBH-589; NVP-LBH-589;

Panobinostat (LBH-589) is a member of the hydroxamic acid group of histone deacetylase (HDAC) inhibitors that have been shown to impede multiple pathways implicated in cancer and reverse epigenetic events associated with cancer, thereby reducing survival and inducing apoptosis in cancer cells. Panobinostat is being investigated in various hematological malignancies, including chronic myelogenous leukemia (CML) and multiple myeloma, and in solid tumors.

Reference:

1.Panobinostat is well tolerated and induces clinical responses in cutaneous T-cell lymphoma (CTCL) patients.  "Histone deacetylase inhibitor panobinostat induces clinical responses with associated alterations in gene expression profiles in cutaneous T-cell lymphoma."

Ellis, L., et al.: Clin. Cancer Res. 14:  4500-4510 (2008). Full text;

2.Panobinostat inhibited histone deacetylase and induced acetylation of histone H3 and alpha-tubulin protein in human umbilical vein endothelial cells (HUVEC), which resulted in induction of G(2)-M cell cycle arrest and inhibition of HUVEC proliferation and viability.  Panobinostat at noncytotoxic concentrations inhibited endothelial tube formation, Matrigel invasion, AKT activity, extracellular signal-regulated kinase 1/2 phosphorylation and chemokine receptor CXCR4 expression.  It aslo reduced angiogenesis and PC-3 tumor growth in mice. "Targeting tumor angiogenesis with histone deacetylase inhibitors: the hydroxamic acid derivative LBH589."  

Qian, D.Z., et al.: Clin. Cancer Res. 12:  634-642 (2006); Full text;

3."Preliminary evidence of disease response to the pan deacetylase inhibitor panobinostat (LBH589) in refractory Hodgkin Lymphoma."
Dickinson et al.: B J Haematology, 147, 97–101 (2009); Full text;

The product is only for R&D purpose,not for human use.We will not take any responsibility for illegal use.

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