Antia Laboratories Inc.

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Tacrolimus


CAS Number: 104987-11-3

Mol. Formula: C44H69NO12

Melting Point: 113-115°C

Mol. Weight: 804.02

Synonyms:
FR 900506; FK506; Fujimycin; L 679934; Prograf; Protopic; TacroBell; Tacrolimus; Tsukubaenolide; 

Appearance: White Solid

Aplications:
An immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+. Tacrolimus is also a potent  immunomodulator that is effective in the treatment of inflammatory bowel disease(IBD).

References:

1.Tacrolimus versus ciclosporin as primary immunosuppression for kidney transplant recipients: meta-analysis and meta-regression of randomised trial data. BMJ,DOI:10.1136/bmj.38569.471007.AE Ask for this article

2.Cyclosporine Microemulsion and Tacrolimus are Associated with Decreased Chronic Allograft Failure and Improved Long-term Graft Survival as Compared with Sandimmune. American Journal of Transplantation 2002;2:100-104 Ask for this article

3.Local Immune Regulation of Mucosal Inflammation by Tacrolimus. Dig Dis Sci (2010) 55:2514–2519 Ask for this article

4.Factors affecting variability in distribution of tacrolimus in liver transplant recipients. Br J Clin Pharmacol 2003;57:3;298-309 Ask for this article

5.Intravitreal injection of Tacrolimus (FK506) suppresses ongoing experimental autoimmune uveoretinitis in Rats. Br J Ophthalmol 2007;91:237–242 Ask for this article

6.The Pittsburgh Randomized Trial of Tacrolimus Compared to Cyclosporine for Hepatic Transplantation. J Am Coll Surg. 1996 August ; 183(2): 117–125 Ask for this article

7."Synthesis and Characterization of an Epimer of Tacrolimus, an Immunosuppressive Drug." Skytte. et al.: J. Nat. Prod. 2010, 73, 776–779 Full text;

8-Epitacrolimus, a new L-pipecolic acid macrolide lactone, was obtained by base-catalyzed epimerization of tacrolimus (FK-506), an important immunosuppressive drug, and its structure determined by a single-crystal X-ray diffraction method. The compound was fully characterized by spectroscopic techniques. The epimer is of importance due to its potential biological effects as well as because of its possible formation during formulation, handling, and use of tacrolimus products.

4. Baumgart DC, MacDonald JK, Feagan BG (2008). "Tacrolimus (FK506) for induction of remission in refractory ulcerative colitis.". Cochrane Database Syst Rev 16 (3): CD007216. doi:10.1002/14651858.CD007216. PMID 18646177. 

The product is only for R&D purpose,not for human use.We will not take any responsibility for illegal use.

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